谭誉宇
职称:副教授 研究方向:生物传感和微流控芯片 联系电话:07348281955 E-mail:tanyuyu@usc.edu.cn |
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个人简介
谭誉宇,男,博士,副教授,硕士生导师,现任bwin国际副经理。2014年12月,博士毕业于湖南大学化学化工学院分析化学专业,师从王柯敏教授;2015年4月,进入厦门大学化学化工学院杨朝勇教授课题组做博士后研究;2017年6月,博士后出站,进入bwin国际生物医学工程系担任专任教师。本人主要研究方向为生物传感和微流控芯片,包括核酸适配体和多肽等分子探针的筛选,肿瘤细胞和组织成像,肿瘤标志物和细胞检测,肿瘤细胞捕获分析,穿戴式传感器,微流控芯片的加工及应用,数字微流控等方面的相关研究,在Lab on a Chip、Analytical Chemistry、Biosensors and Bioelectronics等期刊上发表论文共10余篇,授权专利5项,主持国家自然科学基金青年项目、湖南省自然科学基金、湖南省教育厅项目、博士后基金、校博士启动基金项目等,参与国家自然科学基金2项,主持教研教改课题和虚拟仿真课题实验教学项目各1项。
主要课题
1.湖南省教育厅优秀青年项目,基于数字微流控的自动化多肽筛选系统研究,21B0427,2022.01-2024-12,6万元,主持。
2.湖南省自然科学基金面上项目,人结肠癌细胞特异性核酸适配体的筛选及其在生物医学传感中的应用,2020JJ4533,5 万元,2020.01- 2022.12,主持。
3.bwin国际博士启动基金项目,特异性多肽分子探针筛选新方法的建立及其在肿瘤细胞成像和检测方面的应用,190XQD046,20 万元,2020.01- 2022.12,主持。
4.国家自然科学基金青年项目,特异性肿瘤穿透小分子肽链的筛选及其在生物医学中的应用,81602206,18 万元,2017.01- 2019.12,主持。
5.中国博士后科学基金项目,病毒探针的构建和筛选及在即时检测中的应用,2016M592089,5 万元,2016.01- 2017.05,主持。
6.国家自然科学基金面上项目,核酸适体功能化微流控芯片用于外泌体高效富集与可控释放及在肿瘤检测与转移机制的研究,81772287,56 万,2018.01-2021.12,在研,参加。
7.国家自然科学青年科学基金项目,“开关型”荧光纳米探针用于活细胞内生物分子的检测,21205032,25 万元,2013.01- 2015.12,参加。
8.bwin国际虚拟仿真实验教学项目,微流控芯片制备工艺虚拟仿真实验教学项目,000900009031,5 万元,2020.01- 2021.12,主持。
9.bwin国际教学改革研究课题,新工科背景下的课程教学改革探索-以生医专业英语为例,192JXJ158,0.3 万元,2019.10- 2021.09,主持。
主要论文
1. Junxia Wang#, Yuyu Tan#, Jiajun Ling, Mingxia Zhang, Liang Li, Wenli Liu, Mengjiao Huang, Jia Song, Ao Li, Yanling Song, Chaoyong Yang, Zhi Zhu*, Highly paralleled emulsion droplets for efficient isolation, amplification, and screening of cancer biomarker binding phages, Lab on a Chip, 2021, 21, 1175-1184.
2. Jingjing Hou*#, Yuyu Tan#, Chen Su, Tao Wang, Zhixing Gao, Dan Song, Jiabao Zhao, Yueting Liao, Xiaotian Liu, Ying Jiang, Qian Feng, Zhong Wan*, Yongsheng Yu*, Inhibition of protein FAK enhances5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways, Computational and Structural Biotechnology Journal, 2020, 18, 125-136.
3. Yi-Fei Lou#, Yong-Bo Peng, Xiaowei Luo, Zhiming Yang, Ruifeng Wang, Dewen Sun, Lingxiangyu Li, Yuyu Tan, Jiahao Huang, Liang Cui , A universal aptasensing platform based on cryonase-assisted signal amplification and graphene oxide induced quenching of the fluorescence of labeled nucleic acid probes: application to the detection of theophylline and ATP, Microchimica Acta, 2019, 186: 494.
4. Yuyu Tan#, Wenli Liu, Zhi Zhu*, Lijun Lang, Junxia Wang, Mengjiao Huang, Mingxia Zhang, Chaoyong Yang*, Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells, Analytical and Bioanalytical Chemistry, 2018, 410, 1071-1077.
5. Yuyu Tan#, Tian Tian, Wenli Liu, Zhi Zhu* and Chaoyong J. Yang, Advance in phage display technology for bioanalysis, Biotechnology Journal, 2016, 11, 732-745.
6. Yuyu Tan#, Qiuping Guo#, Xiayu Zhao, Xiaohai Yang, Kemin Wang,* Jin Huang, Yu Zhou, Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification. Biosensors and Bioelectronics, 2014, 51, 255-260.
7. Yuyu Tan#, Qiuping Guo#, Qin Xie, Kemin Wang,* Baoyin Yuan, Yu Zhou, Jianbo Liu, Jin Huang, Xiaoxiao He, Xiaohai Yang, Chunmei He, Xiayu Zhao, Single-Walled Carbon Nanotubes (SWCNTs)-Assisted Cell-Systematic Evolution of Ligands by Exponential Enrichment (Cell-SELEX) for Improving Screening Efficiency, Analytical Chemistry, 2014, 86, 9466-9472.
8. Qin Xie#, Yuyu Tan#, Qiuping Guo,* Kemin Wang,* Baoyin Yuan, Jun Wan, Xiayu Zhao, A fluorescent aptasensor for sensitive detection of human hepatocellular carcinoma SMMC-7721 cells based on graphene oxide, Analytical Methods, 2014, 6, 6809-6814.
9. Qiaoyi Wu#, Liang Wu, Yuzhe Wang, Zhi Zhu, Yanling Song, Yuyu Tan, Xing-Fu Wang, Jiuxing Li, Dezhi Kang, Chaoyong James Yang*, Evolution of DNA aptamers for malignant brain tumor gliosarcoma cell recognition and clinical tissue imaging. Biosensors and Bioelectronics, 2016, 80, 1-8.
10. Baoyin Yuan#, Yu Zhou#, Qiuping Guo,* Kemin Wang,* Xiaohai Yang, Xiangxian Meng, Jun Wan, Yuyu Tan, Zhixiang Huang, Qin Xie, Xiayu Zhao, A signal-on split aptasensor for highly sensitive and specific detection of tumor cells based on FRET. Chemical Communications, 2016, 52, 1590-1593.
11. Jun Wan#, Ling Ye, Xiaohai Yang, Qiuping Guo,* Kemin Wang,* Zhixiang Huang, Yuyu Tan, Baoyin Yuan, Qin Xie, Cell-SELEX based selection and optimization of DNA aptamers for specific recognition of human cholangiocarcinoma QBC-939 cells. Analyst, 2015, 140, 5992-5997.
12. Min Lin#, Wenshan Li, Yaning Wang, Xiaohai Yang,* Kemin Wang,* Qing Wang, Pei Wang, Yujie Chang, Yuyu Tan, Discrimination of hemoglobins with subtle differences using an aptamer based sensing array, Chemical Communications, 2015, 51, 8304-8306.
13. Xiaohai Yang#, Xiuzhi Zhang, Kemin Wang,* Qing Wang, Yuyu Tan, Qiuping Guo, Mian Chen, Yu Zhou, Whole cell-SELEX aptamers for fluorescence staining of frozen hepatocellular carcinoma tissues. Analytical Methods, 2014, 6, 3506-3509.
14. Xiaohai Yang#, Yaning Wang, Kemin Wang,* Qing Wang, Pei Wang, Min Lin, Nandi Chen, Yuyu Tan, DNA aptamer-based surface plasmon resonance sensing of human C-reactive protein, RSC Advances, 2014, 4, 30934-30937.
15. Qiuping Guo#, Xiayu Zhao, Qin Xie, Kemin Wang,* Jun Wan, Baoyin Yuan, Yuyu Tan, Label-free Fluorescence Signal Amplifying Detection of DNA Based on Hairpin Probe and Exo Ⅲ, Chemical Journal of Chinese Universities, 2014, 35, 1646-1651.
专利成果
1. 谭誉宇,段紫薇,吴兴月,便携式手动离心机,2022.01.18,中国,ZL202121382602.X。
2. 王柯敏,谭誉宇,郭秋平,羊小海,何晓晓,核酸适配体及其衍生物、筛选方法和应用,2017.01.11,中国,ZL201410111108.8。
3. 王柯敏,郭秋平,叶玲,羊小海,谭誉宇,何晓晓,一种核酸适配体及其衍生物、核酸适配体的筛选方法及在检测人胆管癌细胞株中的应用,2015.04.29, 中国,ZL201310099114.1。
4. 王柯敏,郭秋平,刘小丹,羊小海,谭誉宇,可用于检测人肝癌细胞株Bel-7404 的核酸适体及其筛选方法和应用,2014.06.04,中国,ZL201210259171.7。
5. 王柯敏,郭秋平,周玉,羊小海,谭誉宇,可用于检测人肝癌细胞株 SMMC-7721 的核酸适体及其筛选方法和应用,2013.08.28,中国,ZL201210259027.3。
讲授课程
本科生:《放射生物学》、《生物化学》、《生物医学的法律与伦理》